Enzymatic large-scale synthesis of MUC6-Tn glycoconjugates for antitumor vaccination
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چکیده
منابع مشابه
Enzymatic large-scale synthesis of MUC6-Tn glycoconjugates for antitumor vaccination.
In cancer, mucins are aberrantly O-glycosylated, and consequently, they express tumor-associated antigens such as the Tn determinant (alpha-GalNAc-O-Ser/Thr). As compared with normal tissues, they also exhibit a different pattern of expression. In particular, MUC6, which is normally expressed only in gastric tissues, has been detected in intestinal, pulmonary, colorectal, and breast carcinomas....
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ژورنال
عنوان ژورنال: Glycobiology
سال: 2006
ISSN: 1460-2423,0959-6658
DOI: 10.1093/glycob/cwj082